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Many more women could be helped by a new type of breast cancer drug, say experts
Biological therapies are currently only available as part of clinical trials, but hold great promise
Experts estimate as many as one in five patients might benefit
Around 10,000 women a year in the UK might benefit from a new type of breast cancer treatment, say scientists.
Biological therapies can help fight breast cancers caused by rare, inherited genetic errors like the BRCA one actress Angelina Jolie carries.
Now a new study by experts at the Wellcome Trust Sanger Institute suggests these targeted drugs may also work in many other women who do not have these risky genes.
The drugs could be effective in one in five breast cancers, say the researchers.
That's 20% of patients - far more than the 1 to 5% who develop the cancer alongside having faulty BRCA genes.
One biological therapy or PARP inhibitor, called olaparib, is already used on the NHS to treat advanced ovarian cancer.
It is not yet approved as a breast cancer drug, although some UK women are taking it in clinical trials.
For the latest work, published in the journal Nature Medicine, the researchers looked at the genetic make-up of breast cancer in 560 different patients.
They found a significant proportion of them had genetic errors or "mutational signatures" that were very similar to faulty BRCA.
Given the close similarity, these cancers might be treatable with biological therapies too, they reasoned.
They recommended clinical trials to confirm this.
Baroness Delyth Morgan, from Breast Cancer Now, called the early results "a revelation".
"We hope it could now lead to a watershed moment for the use of mutational signatures in treating the disease," she said.
One of the researchers, Dr Helen Davies, said there was also the potential to treat other types of cancers with these drugs.
Biological therapies have already had some promising results for treating prostate cancer.
High-risk genes
Carrying certain gene mutations, like faulty BRCA, increases a woman's risk of developing breast cancer, although it does not mean she will definitely go on to get cancer.
Some women - like Angelina Jolie - opt to have surgery to have their breasts removed to lower their lifetime risk.